Protein Oxidation And Aging

Twenty years ago, it was considered a well-established observation that oxidized proteins, metrical as protein carbonylics utilize 2,4-dinitrophenylhydrazine (DNPH), accumulate during aging (1). The age-related increase in protein carbonyl content was report in human adept (2), gerbil brain (3), rat liver (4), and flies (5-7). Protein carbonyl content in mouse brain was found to be correlated with age-related decrease of cognitive and motor performance (8). Those describe increase of oxidized proteins during aging received no fool away exception until Cao and Cutler published their results (9, 10). They showed that the protein carbonyls could not be reliably measured in normal crude tissue extracts by using the DNPH manner (9). Now, the history seems to stand with their detrimental results because it is quite troublesome to regain solid data published in this ampere-second and reinforcement the age-related accumulation of protein carbonyls. In addition, protein carb onyls in rat course did not change with the oxidative stress in the nationwide Biomarkers of aerophilic Stress Study using acute CCl4 toxic condition as a model (11). Protein oxidation and aging or the superior free radical theory of aging is consequently bowl a wide-open area waiting for unfermented and bare-ass technologies to make real advances. At the same time, scientific journals imply to change their general practice of not publish negative findings. Reference 1. E. R. Stadtman, Science 257, 1220 (1992). 2. C. D. Smith et al., Proc. Natl Acad. Sci. regular armament 88, 10540 (1991). 3. J. M. Carney et al., Proc. Natl Acad. Sci. the States 88, 3633 (1991). 4. L. D. Youngman, K. J. Park, Proc. Natl Acad. Sci. USA 89, 9112 (1992). 5. R. S. Sohal et al., Proc. Natl Acad. Sci. USA 90, 7255 (1993). 6. W. C. Orr and R. S. Sohal, Science 263, 1128 (1994). 7. L. Yan, R. L. Levine, R. S. Sohal, Proc. Natl Acad. Sci. USA 94, 11168 (1997). 8. M. J. Forster et al., Proc. Natl Acad. Sci. USA 93, 4765 (19! 96). 9. G. Cao and R. G. Cutler, Arch. Biochem....If you want to get a full essay, order it on our website: OrderCustomPaper.com

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